I had a similar problem when I got my new computer and shifitng to only running on a single core fixed it for me but I did not do it the way you did.
I solved the problem by editing the nwnplayer.ini file.
Now, I'm not sure which number was the original one but I editet where it says "Client CPU Affinity" and switched the number from whetever it was to -2 (( Client CPU Affinity=-2) running on a pentium i5 processor).
Perhaps it might be of some help but please just remember to back-up the file before editing in it =) and if not, I'm sadly out of ideas =(
-Render